The Curriculum provides a solid knowledge on complex biological systems focused on structural and functional biochemistry of proteins and nucleic acids, integrating notions focused on protein/ligand interactions (i.e. salivary proteins, or interaction viral proteins/small molecules), protein/protein interactions (i.e. viral vs cellular proteins interactions), proteins/nucleic acid interactions (i.e. DNA for proteins involved in autoimmune diseases, RNA for proteins involved in innate immune system down-regulation).
More specifically, the investigational areas for this curriculum are:
- Proteomics and peptidomics investigations of body fluids, tissues and cells (saliva, CSF, BALF, brain, etc.) by LC-MS/MS and 2-DE-MS/MS platforms to assess protein/peptide expression profile and PTMs in health and disease, in drug-treated samples, and to discover, identify and quantify new disease biomarkers.
- Identification, characterization and exploitation of new viral targets
- Analysis of human endogenous retrovirus sequences