Chiara Sinico

 
Chiara Sinico

Chiara Sinico

Address: Department of Life and Environmental Sciences, Unit of Drug Sciences, Via Ospedale, 72, 09124 Cagliari
Phone: +39 0706758555
Fax:
Email: sinico@unica.it

Curriculum vitae

1990: Graduate in Pharmaceutical Chemistry and Technology, University of Cagliari

1990-1991: Post graduate grant, University of Milan

1993-2011: Researcher fellow in Pharmaceutical Technology, University of Cagliari

2011-present: Associate Professor in Pharmaceutical Technology, University of Cagliari

Research Topics

  • Micro and nanoparticles as carrier for cutaneous drug delivery.
  • Preparation, characterization and evaluation of magnetoliposomes
  • Solubility and stability studies of drug nanocrystals

Research projects

  • 2000-2001:Assessorato dell’Igiene e Sanità e dell’Assistenza Sociale della Regione Sardegna “Antivirali fitoterapici: preparazione ed ottimizzazione delle caratteristiche tecnologiche e biofarmaceutiche
  • 2004-2005:COFIN Prot. 2004039431_002  “Fitoterapici e Prodotti Salutistici di Origine Vegetale: studi tecnologici  per il miglioramento della loro qualità e sicurezza d’uso”.
  • 2006-2009:Regione Autonoma della Sardegna Progetto P1-Azione A1”Laboratori tecnologici del distretto della biomedicina e delle tecnologie per la salute
  • 2009-2010:Fondazione Banco di Sardegna: “Carrier micro e nanoparticellari per la veicolazione di fitocomplessi”
  • 2009-2012:Azioni Integrate Italia-Spagna; ; Physico-chemical properties of nanosystems and their applications in the pharmaceutical field
  • 2012-in progress:L.R. 2007 n. 7, COD. F71J110012220002, “Progettazione di leghe nanostrutturate”.
  • 2012-in progress:PRIN Prot. 2010H834LS_004, “Tecnologie avanzate per la veicolazione di molecole farmacologicamente attive attraverso le barriere biologiche dell’organismo”

Scientific society memberships

  • A.D.R.I.T.E.L.F. (Italian Association of Teachers and Researchers in Pharmaceutical Technology)
  • Controlled Release Society
  • International Liposome Society
  • Società Farmaceutica del Mediterraneo Latino
  • Società Chimica Italiana

Teaching activities

1996-2010: Pharmaceutical Technology and LegislationII in the Master Degrees in Pharmaceutical Chemistry and Technology.

2011-present:Pharmaceutical Technology and Legislation II and Industrial Manufacture of Medicines in the Master Degree in Pharmaceutical Chemistry and Technology.

2012-present: Legislation of Dietetic Products and Food Supplements in the Master Degree in Food and Nutrition  Sciences

Publications from 2008 to 2013

  • C. Sinico*, C. Caddeo, D. Valenti, A.M. Fadda, A.R. Bilia, F.F. VincieriLiposomes as carriers for verbascoside: stability and skin permeation studies. Journal of Liposome Research, 18 (1), 83-90 (2008).
  • M. Manconi, S. Mura, S. Madrigal-Carballo, C. Sinico, A.M. Fadda, A.O. Vila, F. MolinaComposite soy lecithin-decylpolyglucoside vesicles: a theoretical and experimental study. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 323, 175-179 (2008)
  • F. Lai, C. Sinico, D. Valenti, M.L. Manca, A.M. FaddaNanoemulsions as vehicle for topical 8-methoxypsoralen delivery.Journal of Biomedical Nanotechnology , 4, 1-5 (2008)
  • C. Caddeo, K. Teskač, C. Sinico, J. KristlEffect of resveratrol incorporated in liposomes on proliferation and UV-B protection of cells. International Journal of Pharmaceutics, 363, 183-191 (2008)
  • M. Manconi, F. Marongiu, G. Ennas, A. Scano, C. Sinico, D. Valenti, A. M. Fadda.Liposomes for (trans)dermal delivery of tretinoin: influence of drug concentration and vesicle composition. Journal of Drug Delivery Science and Technology, 18, 309-313 (2008)
  • M. Zaru, C. Sinico, A. De Logu, , C. Caddeo, F.Lai, M.L. Manca, A.M. Fadda.Rifampicin loading liposomes for the passive targenting to alvelolar macrophages: vitro and in vivo evaluation. Journal of Liposome Research, 19, 68-76 (2009).
  • M. Manconi, J. Pendás, N. Ledón, T. Moreira, C. Sinico, L. Saso, A.M.FaddaPhycocyanin liposomes for topical anti-inflammatory  activity: in-vitro in-vivo  studies. Journal of Pharmacy and Pharmacology, 61, 423-430 (2009).
  • F. Lai, C. Sinico, G. Ennas, F. Marongiu, G. Marongiu, A.M. Fadda.Diclofenacnanosuspensions: influence of preparation procedure and crystal form on drug dissolution behaviour. International Journal of Pharmaceutics,373, 124-132 (2009)
  • M. Manconi, S. Mura, C. Sinico, A.M. Fadda, O. Vila, F. MolinaDevelopment and Characterization of liposomes containing glycols as Carriers for Diclofenac. Colloids and Surfaces A: Physicochemical and Engineering Aspects 342, 53-58 (2009).
  • C. Sinico, A.M. FaddaVesicular carriers for dermal drug delivery. Expert Opinion on Drug Delivery,6, 813-825 (2009)
  • S. Mura, M. Manconi, C. Sinico, D. Valenti, A.M. FaddaPenetration enhancer-containing vesicles (PEVs) as carriers for cutaneous delivery of minoxidil. International Journal of Pharmaceutics, 380, 72-79 (2009).
  • M. Manconi, C. Sinico, C. Caddeo, D. Valenti, , A. Ofelia, A.M. Fadda.Penetration enhancer containing vesicles  as carriers for dermal delivery of tretinoin. International Journal of Pharmaceutics, 412, 37-46 (2011)
  • A. Floris, A. Ardu, A. Musinu, G. Piccaluga, A.M. Fadda, C. Sinico, C. Cannas. SPION@Liposomes hybrid nanoarchitectures with high density SPION association

    Soft Matter, 7, 6239-6247 (2011)

  • M. Chessa, C. Caddeo, D. Valenti, M. Manconi, C. Sinico, A. M. Fadda.Effect of penetration enhancer containing vesicles on the percutaneous delivery of quercetin through new born pig skin. Pharmaceutics, 3, 497-509 (2011)
  • F. Lai, E. Pini, G. Angioni, M.L. Manca , J. Perricci, C. Sinico*, A.M. Fadda. Nanocrystals as tool to improve piroxicam dissolution rate in novel orally disintegrating tablets. European Journal of Pharmaceutics and Biopharmaceutics 79, 552-558(2011).
  • L. Montenegro, C. Sinico, I. Castangia, C. Carbone, G. PuglisiIdebenone-loaded solid lipid nanoparticles for drug delivery to the skin: in vitro evaluation. International Journal of Pharmaceutics, 434, 169-174 (2012)
  • M. Manconi, C. Caddeo, C. Sinico, D. Valenti, M.C. Mostallino, S. Lampis, M. Monduzzi, A.M. Fadda Penetration enhancer-containing vesicles: composition dependence of structural feature and skin penetration ability. European Journal of Pharmaceutics and Biopharmaceutics, 82, 352-359(2012).
  • M.L. Manca, C. Sinico, A.M. Maccioni, O. Diez, A.M. Fadda, M. Manconi.Composition influence over pulmonary delivery of rifampicin liposomes.Pharmaceutics, 4, 590-606, (2012).
  • C. Caddeo, M. Manconi, D. Valenti, A. M. Maccioni, A. M. Fadda, C. Sinico. The role of Labrasol® in the enhancement of the cutaneous bioavailability of minoxidil in phospholipid vesicles. Research Journal of Pharmacy and Technology, 5, 1915-1921 (2012).
  • A. Floris, C. Meloni, F. Lai, F. Marongiu, A.M. Maccioni, C. Sinico*. Cavitation effect on chitosan nanoparticle size:  a  possible approch to protect drugs from ultrasonic stress. Carbohydrate Polymers, 94, 619-625 (2013)
  • M. Pilloni, G. Ennas, M. Casu, A.M. Fadda, F. Frongia, F. Marongiu, R. Sanna, A. Scano, D. Valenti, C.Sinico.Drug silica nanocomposite: preparation, characterization and skin permeation studies

    Pharmaceutical Development and Technology, 18, 626-633 (2013).

  • S. Murgia, A.M. Falchi, M. Carboni, S. Lampis, C. Sinico, M.L. Manca, J. Schmidt, Y. Talmon,  M. Monduzzi. Physicochemical, Cytotoxic, and Dermal Release Features of a Novel Cationic Liposome Nanocarrier. Advanced Healthcare Materials, 2, 692-701 (2013)
  • F. Lai, A.M. Fadda C. Sinico.Liposomes for brain delivery. Expert Opinion on Drug Delivery, 10, 1003-1022 (2013)
  • S. Mura, M. Manconi, A.M. Fadda, M.C. Sala, J. Perricci, E. Pini, C. Sinico*. Penetration enhancer-containing vesicles (PEVs) as carriers for  cutaneous delivery of minoxidil: in vitro evaluation of drug permeation by infrared spectroscopy. Pharmaceutical Development and Technology, 18, 1339-1345 (2013).
  • C. Caddeo, M. Manconi; A.M. Fadda, F. Lai, S. Lampis; O. Diez Sales, C. Sinico*.Nanocarriers for antioxidant resveratrol: formulation approach, vesicle self-assembly and stability evaluation. Colloids and Surfaces B: Biointerfaces, 11, 327-332 (2013).
  • M.L. Manca, M. Zaru, M. Manconi, F. Lai, D. Valenti, C. Sinico, A.M. Fadda. Glycerosomes: a new tool for effective dermal and transdermal drug delivery.International Journal of Pharmaceutics, 455, 66-74 (2013).
  • I. Castangia, M.L. Manca, P. Matricardi, C. Sinico, Lampis S., X. Fernàndez-Busquets, A.M. Fadda, M. Manconi.Effect of diclofenac and glycol intercalation on structural assembly of phospholipid lamellar vesicles. International Journal of Pharmaceutics, 456, 1-9 (2013).
  • F. Lai, R. Pireddu, F. Corrias, A. M. Fadda, D. Valenti, C. Sinico.Nanosuspension improves tretinoinphotostability and delivery to the skin.International Journal of Pharmaceutics, 458, 104-109 (2013).
  • A. Floris, C. Sinico*, A.M. Fadda, F. Lai, F. Marongiu, A. Scanu, M. Pilloni, F. Angius, C. Vazquez-Vasquez, G. EnnasCharacterization and Cytotoxicity Studies on Liposome-Hydrophobic Magnetite Hybrid Colloids. Journal of Colloid and Interface Science, 425, 118-127 (2014).
  • F. Lai, E. Pini, F. Corrias, J. Perricci, M. Manconi, A.M. Fadda, C. Sinico. Formulation strategy and evaluation of nanocrystalpiroxicam orally disintegrating tablets manufacturing by freeze-drying. International Journal of Pharmaceutics 1, 27-33 (2014).
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