Maria Teresa Sanna


Maria Teresa Sanna

Address: Dipartimento di Scienze della Vita e dell’Ambiente
Cittadella Universitaria, Monserrato
Phone: +39 070 675 4509
Fax: +39 070 675 4523

Curriculum vitae


  • 1991-1993: Research Fellow of CNR
  • 06.1993-12.1993: Research trainee at the Chemistry Institute, Catholic University, Rome
  • 12.1995-05.2006: Assistant Professor (BIO/10- Biochemistry) School of Pharmacy, UNICA
  • from 06.2006 to present: Associate Professor (BIO/10- Biochemistry) at DISVA, UNICA


  • 1990-91: Research Fellow of the Italian Ministry of Foreign Affair at the Zoological Laboratory of the University of Bergen
  • 1994-96: Post Doctoral Fellow at the Department of Biochemistry and Molecular Biology – University of Maryland at Baltimore (USA)
  • 2002 and 2003: member of the XVII and XVIII Italian Antarctic Scientific Expedition (Baia Terra Nova) for the Research Program: Physiological, biochemical and molecular basis of the evolutionary adaptation in Antarctic teleosts


  • 2000/01 to present: Applied Biochemistry at the single cycle degree course in Chemistry and Pharmaceutical Technologies  (CTF), UNICA
  • 2011/12- to present: Nutritional Biochemistry at the II level degree course in Food and Nutritional Sciences, UNICA
  • 2000/01 to 2009/2010: Biochemistry at the Herbal Sciences and Technologies Undergraduate Degree, Pharmacy School, UNICA
  • 2009/10 – 2012/2013: Applied Biochemistry at the Pharmacy School, UNICA

Lines of research

Proteomic and peptidomic analysis of body fluids and tissues by LC-MS and 2D-MS platforms to assess protein/peptide expression profile and PTMs in health and drug-treated samples and to discover, identify and quantify new disease biomarkers.

Recombinant protein expression in Escherichia coli


Publications from 2005 to 2015

Integrated proteomic platforms for the comparative characterization of medulloblastoma and pilocytic astrocytoma pediatric brain tumors: a preliminary study.
Martelli C, Iavarone F, D’Angelo L, Arba M, Vincenzoni F, Inserra I, Delfino D, Rossetti DV, Caretto M, Massimi L, Tamburrini G, Di Rocco C, Caldarelli M, Messana I, Castagnola M, Sanna MT, Desiderio C.
Mol Biosyst. 2015, 11(6):1668-83.

Chrono-proteomics of human saliva: variations of the salivary proteome during human development.
Messana I, Cabras T, Iavarone F, Manconi B, Huang L, Martelli C, Olianas A, Sanna MT, Pisano E, Sanna M, Arba M, D’Alessandro A, Desiderio C, Vitali A, Pirolli D, Tirone C, Lio A, Vento G, Romagnoli C, Cordaro M, Manni A, Gallenzi P, Fiorita A, Scarano E, Calò L, Passali GC, Picciotti PM, Paludetti G, Fanos V, Faa G, Castagnola M.
J Proteome Res. 2015, 14(4):1666-77.

Top-down analytical platforms for the characterization of the human salivary proteome.
Cabras T, Iavarone F, Manconi B, Olianas A, Sanna MT, Castagnola M, Messana I.
Bioanalysis 2014, 6(4):563-81.

Modifications of the acidic soluble salivary proteome in human children from birth to the age of 48months investigated by a top-down HPLC-ESI-MS Platform.
Manconi B, Cabras T, Pisano E, Sanna MT, Olianas A, Fanos V, Faa G, Nemolato S, Iavarone F, Castagnola M, Messana I.
J Proteomics 2013, 91:536-43.

The hemoglobin system of the serpent eel Ophisurus serpens: structural and functional characterization.
Manconi B, Pellegrini M, Messana I, Sanna MT, Castagnola M, Iavarone F, Coluccia E, Giardina B, Olianas A.
J Comp Physiol B. 2013, 183(7):905-19.

Top-down HPLC-ESI-MS detection of S-glutathionylated and S-cysteinylated derivatives of cystatin B and its 1-53 and 54-98 fragments in whole saliva of human preterm newborns.
Iavarone F, Cabras T, Pisano E, Sanna MT, Nemolato S, Vento G, Tirone C, Romagnoli C, Cordaro M, Fanos V, Faa G, Messana I, Castagnola M.
J Proteome Res. 2013, 12(2):917-26.

Functional properties of the newly observed (G)γ-chain fetal hemoglobin variant Hb F-Monserrato-Sassari (HBG2:c.280T>C) or [(G)γ93 (F9) Cys→Arg].
Pellegrini M, Manconi B, Olianas A, Sanna MT, Meloni C, Pirastru M, Mereu P, Leoni G, Masala B, Manca L.
Biochim Biophys Acta. 2011, 1810(12):1272-7.

Biotechnological implications of the salivary proteome.
Castagnola M, Cabras T, Vitali A, Sanna MT, Messana I.
Trends Biotechnol. 2011, 29(8):409-18.

Striped mullet (Mugil cephalus) hemoglobin system: multiplicity and functional properties.
Olianas A, Meloni C, Messana I, Sanna MT, Castagnola M, Manconi B, Salvadori S, Giardina B, Pellegrini M.
J Comp Physiol B. 2011, 1(2):187-97.

The surprising composition of the salivary proteome of preterm human newborn.
Castagnola M, Inzitari R, Fanali C, Iavarone F, Vitali A, Desiderio C, Vento G, Tirone C, Romagnoli C, Cabras T, Manconi B, Sanna MT, Boi R, Pisano E, Olianas A, Pellegrini M, Nemolato S, Heizmann CW, Faa G, Messana I.
Mol Cell Proteomics. 2011 Jan;10(1):M110.003467.

Oxygen-linked modulation of erythrocyte metabolism: state of the art.
Castagnola M, Messana I, Sanna MT, Giardina B
Blood Transfus. (2010) Suppl 3: s53-58.

Characterization of two isoforms of human SPRR3 from saliva of preterm human newborn and autoptic fetal oral mucosa, parotid and submandibular gland samples
Manconi B, Cabras T, Pisano E, Nemolato S, Inzitari R, Iavarone F, Fanali C, Sanna MT, Tirone C, Vento G, Romagnoli C, Faa G, Castagnola M, Messana I.
Biochem Biophys Res Commun. (2010) 398: 477-481.

Structural characterization of a new statherin from pig parotid granules.
Manconi B, Fanali C, Cabras T, Inzitari R, Patamia M, Scarano E, Fiorita A, Vitali A, Castagnola M, Messana I, Sanna MT.
J Pept Sci. (2010) 16: 269-275

Expression, purification, phosphorylation and characterization of recombinant human statherin.
Manconi B, Cabras T, Vitali A, Fanali C, Fiorita A, Inzitari R, Castagnola M, Messana I, Sanna MT.
Protein Expr Purif. (2010) 69: 219-225.

Structural and functional characterization of Delphinus delphis hemoglobin system.
Manconi B, Messana I, Maggiani F, Olianas A, Pellegrini M, Crnjar R, Castagnola M, Giardina B, Sanna MT.
J Comp Physiol B. (2009) 179: 971-983.

The oxygen-binding modulation of hemocyanin from the Southern spiny lobster Palinurus gilchristi
Olianas A, Manconi B, Masia D, Sanna MT, Castagnola M, Salvadori S, Messana I, Giardina B, Pellegrini M.
J Comp Physiol B. (2009) 179: 193-203.

Trafficking and postsecretory events responsible for the formation of secreted human salivary peptides: a proteomics approach
Messana I, Cabras T, Pisano E, Sanna MT, Olianas A, Manconi B, Pellegrini M, Paludetti G, Scarano E, Fiorita A, Agostino S, Contucci AM, Calò L, Picciotti PM, Manni A, Bennick A, Vitali A, Fanali C, Inzitari R, Castagnola M.
Mol Cell Proteomics. (2008) 7: 911-926.

Structural and functional characterization of haemocyanin from the anemone hermit crab Dardanus calidus
Podda G, Manconi B, Olianas A, Pellegrini M, Messana I, Mura M, Castagnola M, Giardina B, Sanna MT.
J Biochem. (2008) 143: 207-216.

Alkaline Bohr effect of bird hemoglobins: the case of the flamingo
Sanna MT, Manconi B, Podda G, Olianas A, Pellegrini M, Castagnola M, Messana I, Giardina B.
Alkaline Bohr effect of bird hemoglobins: the case of the flamingo
Biol Chem.(2007) 388: 787-795.

Functional characterization of the single hemoglobin of the migratory bird Ciconia ciconia
Manconi B, Olianas A, Sanna MT, Messana I, Demurtas L, Castagnola M, Giardina B, Pellegrini M.
Comp Biochem Physiol B Biochem Mol Biol. (2007) 147: 242-249.

HPLC-MS characterization of cyclo-statherin Q-37, a specific cyclization product of human salivary statherin generated by transglutaminase 2
Cabras T, Inzitari R, Fanali C, Scarano E, Patamia M, Sanna MT, Pisano E, Giardina B, Castagnola M, Messana I.
J Sep Sci. (2006) 29: 2600-2608.

The hemocyanin of the shamefaced crab Calappa granulata: structural-functional characterization.
Olianas A, Sanna MT, Messana I, Castagnola M, Masia D, Manconi B, Cau A, Giardina B, Pellegrini M.
J Biochem. (2006)139: 957-966.

Two sites for GTP binding in cathodic haemoglobins from Anguilliformes.Olianas A, Messana I, Sanna MT, Castagnola M, Manconi B, Masia D, Coluccia E, Giardina B, Pellegrini M.
Comp Biochem Physiol B Biochem Mol Biol.(2005) 141: 400-407.

Functional and structural characterization of the myoglobin from the polychaete Ophelia bicornis.
Sanna MT, Manconi B, Castagnola M, Giardina B, Masia D, Messana I, Olianas A, Patamia M, Petruzzelli R, Pellegrini M. Biochem J.(2005) 389: 497-505.

Different isoforms and post-translational modifications of human salivary acidic proline-rich proteins
Inzitari R, Cabras T, Onnis G, Olmi C, Mastinu A, Sanna MT, Pellegrini MG, Castagnola M, Messana I.
Proteomics (2005) 5: 805-815.

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