Education

• 1995: Graduate in Pharmaceutical Chemistry and Technology, University of Cagliari, full marks cum laude
• 1995–99: PhD Student on Tecnologie e legislazione del farmaco e delle molecole bioattive, University of Cagliari.
• 1999: Advance Course on Scienza e Tecnica delle piante Officinali, University of Cagliari
• 2000: Post Doctoral Grant, University of Cagliari
• 2001-04: Research Fellowship, University of Cagliari.
• 2002: Master Internacionales en Formas Farmaceuticas Liposomales, University of Valencia, Spain.
• 2005- present: Research Fellow in Pharmaceutical Technology, University of Cagliari.

Research Topics

• Micro and nanoparticles as carrier for cutaneous drug delivery.
• Preparation, characterization and evaluation of magnetoliposomes
• Solubility and stability studies of drug nanocrystals

Research experienxe abroad

1994: Erasmus project grant, University of Bergen, Norway.

1995: Comett grant, Botanic Garden of Valencia, University of Valencia, Spain.

2001-02: Young researcher project grant, Colloid Chemistry Laboratory, University of Valencia, Spain.

2002-05: Research training, Colloid Chemistry Laboratory, University of Valencia, Spain.

2005-07: Research training , Department of Pharmaceutical Technology, University of Valencia, Spain.

Research topics

• Application of lamellar vesicles as Drug Delivery Systems.
• Dermal and transdermal delivery of natural products and synthetic molecules.
• Design and development of inhalable dosage forms for lung diseases.
• In vitro and in vivo drug release studies from polymeric particles for colon delivery.
• Design and development of innovative nanobiovesicles to improve wound healing.

Teaching activities

2000-2010: tutor for Galenic Laboratory in the Master Degree in Pharmacy.

2005-2010: Cosmetic Product Technology in the Bachelor Degree in Herbal Sciences and Technologies.

2005: ERASMUS teaching on Dermal Drug Delivery Systems, University of Valencia, Spain.

2011– present: Galenic Laboratory (6 CFU) in the Master Degree in Pharmacy.

Research projects

• 2000-01 Progetto Giovani Ricercatori dal titolo “Nuove formulazioni vescicolari come sistemi di rilascio di farmaci”.
• 2008-10 PRIN 2008, Prot. 2008HTJLN2_002, “Idrogeli per il miglioramento della biodisponibilita’ di farmaci e molecole bioattive”.
• 2009-12 “Azioni Integrate Italia-Spagna 2009” in collaborazione con Università degli Studi di Valencia, “Proprietà chimico-fisiche di nanosistemi e loro applicazioni in campo farmaceutico”.
• 2009-10 Fondazione Banco di Sardegna: “Carrier micro e nanoparticellari per la veicolazione di fitocomplessi”.
• 2011 P.O.R. FSE 2007-2013, competitività regionale e occupazione, programma master and back 2010/2011 percorsi di rientro. Assegno di ricerca biennale dal titolo: Progettazione e sviluppo di sistemi innovativi per il rilascio sito specifico di farmaci al colon.
• 2012 PRIN 2010-2011, Prot. 2010H834LS_004, tecnologie avanzate per la veicolazione di molecole farmacologicamente attive attraverso le barriere biologiche dell’organismo.

Publications from 2008 to 2013

• S.Mura, M. Manconi, S. Madrigal-Carballo, C. Sinico, AM. Fadda A. O. Vila, F. Molina. Composite soy lecithin–decylpolyglucoside vesicles: a theoretical and experimental study. Colloids Surf. A-Physiochem.Eng.Asp., 323, 175-179 (2008).
• S. Madrigal-Carballo, M. Manconi, S. Mura, A.O. Vila, F. Molina. An approach to viscoelastic and electrokinetic behaviour of lipidic vesicles covered with chitosan biopolymer. Colloids Surf. A-Physiochem.Eng.Asp., 323, 149-154 (2008)
• M. Manconi, F. Marongiu,  G. Ennas, A. Scano, C. Sinico, D. Valenti, AM. Fadda. Liposomes for (trans)dermal delivery of tretinoin: influence of drug concentration and vesicle composition. J. Drug Deliv. Sci. Tech. 18, 309-313 (2008).
• M. Manconi, J. Pendás, N. Ledón, T. Moreira, C. Sinico, L. Saso, A.M. Fadda. Phycocyanin liposomes for topical anti-inflammatory activity: in-vitro in-vivo studies. J Pharm Pharmac, 61, 423-430 (2009).
• M. Manconi, S. Mura, C. Sinico, A.M. Fadda, A.O. Vila, F. Molina. Development and characterization of liposomes containing glycols as carriers for diclofenac. Colloids Surf.A: Physicochem. Eng. Aspects 342, 53-58 (2009).
• S. Mura, M. Manconi, C. Sinico, D. Valenti, A.M. Fadda. Penetration enhancer-containing vesicles (pevs) as carriers for cutaneous delivery of minoxidil. Int. J Pharm., 380, 72-79 (2009).
• González-Paredes, M. Manconi, C. Caddeo, A. Ramos-Cormenzana, M. Monteoliva-Sánchez, A.M. Fadda. Archaeosomes as carriers for topical delivery of betamethasone dipropionate: in vitro skin permeation study. J Liposome Res. 2, 269–276 (2010).
• M. Manconi, S. Mura, ML.Manca, A.M. Fadda, M. Dolz, M.J. Hernandez, A. Casanovas, O. Diez-Sales. Chitosomes as drug delivery systems for c-phycocyanin: preparation and characterization. Int. J Pharm., 392,  92-100 (2010).
• S. Mura, M. Manconi, D. Valenti, C. Sinico, A.O. Vila, A.M. Fadda. Transcutol containing vesicles for topical delivery of minoxidil. J. Drug Targeting, , 19, 189-196(8) (2011).
• M. Manconi, C. Caddeo, C. Sinico, D. Valenti, M.C. Mostallino, G. Biggio, A.M. Fadda. Ex vivo skin delivery of diclofenac by transcutol containing liposomes and suggested mechanism of vesicle–skin interaction. Eur. J. Pharm. Biopharm., 78, 27-35 (2011).
• C. Mura, M. Manconi, D. Valenti, M.L. Manca, O. Díez-Sales, G. Loy, A.M. Fadda. In vitro study of n-succinyl chitosan for targeted delivery of 5-aminosalicylic acid to colon. Carbohydrate Polymers, 85, 578-583 (2011).
• M. Manconi, C. Sinico, C. Caddeo, A. Ofelia Vila, D. Valenti, A.M. Fadda. Penetration enhancer containing vesicles as carriers for dermal delivery of tretinoin. Int. J Pharm., 412, 37-46 (2011).
• C. Mura, A.Nácher, V.Merino, M. Merino-Sanjuan, C.Carda, A.Ruiz, M. Manconi, G.Loy, A.M.Fadda, O.Díez-Sales. N-succinyl-chitosan systems for 5-aminosalicylic acid colon delivery: in vivo study with tnbs-induced colitis model in rats. Int. J Pharm., 416, 145-154 (2011).
• M. Chessa, C. Caddeo, D. Valenti, M. Manconi, C. Sinico, A.M. Fadda. Effect of penetration enhancer containing vesicles on the percutaneous delivery of quercetin through new born pig skin. Pharmaceutics 3, 497-509 (2011)
• M.L. Manca, M. Manconi, D. Valenti, F. Lai, G. Loy, P. Matricardi, A.M. Fadda. Liposomes coated with chitosan-xanthan gum (chitosomes) as potential carriers for pulmonary delivery of rifampicin. J Pharm Sci. 101(2):566-75 (2012).
• C. Mura, A. Nácher, V. Merino, M. Merino-Sanjuán, M. Manconi, G. Loy, A.M. Fadda, O. Díez-Sales. Design, characterization and in vitro evaluation of 5-aminosalicylic acid loaded n-succinyl-chitosan microparticles for colon specific delivery. Colloids Surf. B-Biointerfaces, 94: 199-205 (2012).
• R. Cassano, S. Trombino, T. Ferrarelli, M.V. Mauro, C. Giraldi, M. Manconi, A.M. Fadda, N. Picci. Respirable rifampicin-based microspheres containing isoniazid for tuberculosis treatment. J. Biomed. Mater. Res. Part A, 100A, 536-542 (2012).
• M. Manconi, C. Caddeo, C. Sinico, D. Valenti, M.C. Mostallino, S. Lampis, M. Monduzzi, A.M. Fadda. Penetration enhancer-containing vesicles: Composition dependence of structural features and skin penetration ability. Eur. J. Pharm. Biopharm., 82, 352-359 (2012).
• C. Caddeo,. M. Manconi, D. Valenti, A.M. Maccioni, A.M. Fadda, C. Sinico. The Role of Labrasol® in the Enhancement of the Cutaneous Bioavailability of Minoxidil in Phospholipid Vesicles. Research J. Pharm. and Tech., 5(12), 1563-1569 (2012).
• M.L. Manca, C. Sinico, A.M. Maccioni, O.Díez-Sales, A.M. Fadda, M. Manconi. Composition Influence on Pulmonary Delivery of Rifampicin Liposomes. Pharmaceutics 4, 590-606 (2012).
• M. Manconi, A. Nácher, V. Merino, M. Merino-Sanjuán, M.L. Manca, C. Mura, S. Mura, A.M. Fadda, O. Díez-Sales. Improving oral bioavailability and pharmacokinetics of liposomal metformin by glycerolphosphate-chitosan microcomplexation. AAPS PharmSciTech, 14, 485-496 (2013).
• C. Caddeo, O. Díez-Sales, D. Valenti, A. Ruiz Saurì, A.M. Fadda, M. Manconi. Inhibition of skin inflammation in mice by diclofenac in vesicular carriers: Liposomes, ethosomes and PEVs. Int. J Pharm., 443, 128-136 (2013).
• D. Pando, C. Caddeo, M. Manconi, A.M. Fadda, C. Pazos Nanodesign of olein vesicles for the topical delivery of antioxidant resveratrol. J. Pharm. Pharmacol., 65, 1158-1167 (2013).
• C. Caddeo, M. Manconi, A.M. Fadda, F. Lai, S. Lampis, O. Diez Sales, C. Sinico Nanocarriers for antioxidant resveratrol: formulation approach, vesicle self-assembly and stability evaluation. Colloids Surf. B-Biointerfaces, 111, 327-332 (2013).
• C. Caddeo, M. Chessa, A. Vassallo, R. Pons, O. Diez Sales, A.M. Fadda, M. Manconi. Extraction, purification and nanoformulation of natural phycocyanin (from Klamath algae) for dermal and deeper soft tissue delivery. J.Biomed. Nanotechnol., 9, 1929–1938 2013.
• S. Mura, M. Manconi, A.M. Fadda, M.C. Sala, J. Perricci, E. Pini, C. Sinico. Penetration enhancer-containing vesicles (PEVs) as carriers for cutaneous delivery of minoxidil: in vitro evaluation of drug permeation by infrared spectroscopy. Pharm. Dev. Technol., 18, 1339-1345 (2013).
• M.L. Manca, R. Cassano, D. Valenti, S. Trombino, T. Ferrarelli, Nevio Picci, A.M. Fadda, M. Manconi. Isoniazid-gelatin conjugate microparticles containing rifampicin for the treatment of tuberculosis. J. Pharm. Pharmacol., 65, 1302–1311 (2013).
• M.L. Manca, M. Manconi, A.M. Falchi, I. Castangia, D. Valenti, S. Lampis, A.M. Fadda, Close-packed vesicles for diclofenac skin delivery and fibroblast targeting. Colloids Surf. B-Biointerfaces, 111, 609-617(2013).
• M.L. Manca, M. Zaru, M. Manconi, F. Lai, D. Valenti, C. Sinico, A.M. Fadda, Glycerosomes: A new tool for effective dermal and transdermal drug delivery. Int. J Pharm., 455, 66– 74 (2013).
• I. Castangia, M.L. Manca, P. Matricardi, C. Sinico, S. Lampis, X. Fernàndez-Busquets, A.M. Fadda, M. Manconi, Effect of diclofenac and glycol intercalation on structural assembly of phospholipid lamellar vesicles. Int. J Pharm., 456, 1-9 (2013).
• C. Caddeo, O. Díez-Sales, R. Pons, X. Fernàndez-Busquets, A.M. Fadda, M. Manconi Topical anti-inflammatory potential of quercetin in lipid-based nanosystems: in vivo and in vitro evaluation. Pharm Res 31, 959-968 (2014).
• I. Castangia, A. Nacher, C. Caddeo, D. Valenti, A.M. Fadda, O. Díez-Sales, A. Ruiz Saurì, M. Manconi Fabrication of quercetin and curcumin bionanovesicles for the prevention and rapid regeneration of full-thickness skin defects on mice. Acta Biomaterialia, 10, 1292–1300 (2014).
• M.L. Manca, I. Castangia, P. Matricardi, S. Lampis, X. Fernàndez-Busquets, A.M. Fadda, M. Manconi Molecular arrangements and interconnected bilayer formation induced by alcohol or polyalcohol in phospholipid vesicles. Colloids Surf. B-Biointerfaces, doi.org/10.1016/j.colsurfb.2014.03.010.
• F. Lai, E. Pini, F. Corrias, J. Perricci, M. Manconi, A.M. Fadda, C. Sinico, Formulation strategy and evaluation of nanocrystal piroxicam orally disintegrating tablets manufacturing by freeze-drying. Int. J Pharm., 1-2, 27-33 (2014).
• C. Caddeo, A. Nácher , O. Diez-Sales , M. Merino-Sanjuan, A.M. Fadda, M. Manconi Chitosan-xanthan gum microparticle-based oral tablet for colon-targeted and sustained delivery of quercetin. J. Microencapsul., accept 2014.
• C Caddeo, M. Manconi, C. Sinico, D. Valenti, C. Celia, M.Monduzzi, A.M. Fadda, Penetration enhancer-containing vesicles: does the penetration enhancer structure affect topical drug delivery? Curr. Drug Targets, accept 2014.