Nicole Grandi

 
Nicole_Grandi

Nicole Grandi
Phone: 070-6754535
Email: nicole.grandi2@gmail.com
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Curriculum vitae

Nicole attained her Biomedical Science master degree cum laude in 2012 at the Alma Mater Studiorum, University of Bologna, with an experimental thesis on the genotypic prediction of the viral tropism in a group of HIV-1 infected patients.

In 2013 she continued her research activities at the Retrovirus Laboratory of the University Hospital Sant’Orsola Malpighi in Bologna, headed by Prof. Maria Carla Re.

In 2014 Nicole joined the PhD program in Life, Environmental and Drug Sciences at the University of Cagliari, and currently she is working in the Laboratory of Molecular Virology under the supervision of Prof. Enzo Tramontano, with a project focused on the Human Endogenous Retroviruses.

Publications

Publications in peer-reviewed journals:

  1. Contribution of Type W Human Endogenous Retrovirus to the Human Genome: Characterization of HERV-W Proviral Insertions and Processed Pseudogenes. Grandi N, Cadeddu M, Blomberg J, Tramontano E. Retrovirology. 2016 Sep 9; 13:67. doi: 10.1186/s12977-016-0301-x
  2. Inhibitory Effect of 2,3,5,6-Tetrafluoro-4-[4-(aryl)-1H-1,2,3-triazol-1-yl]benzenesulfonamide Derivatives on HIV Reverse Transcriptase Associated RNase H Activities. Pala N, Esposito F, Rogolino D, Carcelli M, Sanna V, Palomba M, Naesens L, Corona A, Grandi N, Tramontano E, Sechi M. International Journal of Molecular Sciences, 2016 Aug 20; 17, 1371; doi:10.3390/ijms17081371
  3. Sennoside A, derived from the Traditional Chinese Medicine plant Rheum L., is a new dual HIV-1 inhibitor effective on HIV-1 replication. Esposito F, Carli I, Del Vecchio C, Xu L, Corona A, Grandi N, Piano D, Maccioni E, Distinto S, Parolin C, Tramontano E. Phytomedicine, 2016 Aug 9; S0944-7113(16)30144-1. doi: 10.1016/j.phymed.2016.08.001
  4. Inhibition of HIV-1 Reverse Transcriptase Dimerization by Small Molecules. Tintori C, Corona A, Esposito F, Brai A, Grandi N, Ceresola ER, Clementi M, Canducci F, Tramontano E, Botta M. Chembiochem. 2016 Apr 15;17(8):683-8. doi: 10.1002/cbic.201500668. Epub 2016 Mar 21.
  5. Classification and characterization of human endogenous retroviruses; mosaic forms are common. Vargiu L, Rodriguez-Tomé P, Sperber GO, Cadeddu M, Grandi N, Blikstad V, Tramontano E, Blomberg J. Retrovirology. 2016 Jan 22;13:7. doi: 10.1186/s12977-015-0232-y.
  6. From the traditional Chinese medicine plant Schisandra chinensis new scaffolds effective on HIV-1 reverse transcriptase resistant to non-nucleoside inhibitors. Xu L, Grandi N, Del Vecchio C, Mandas D, Corona A, Piano D, Esposito F, Parolin C, Tramontano E. Journal of Microbiology. 2015 Apr;53(4):288-93. doi: 10.1007/s12275-015-4652-0. Epub 2015 Mar 4.
  7. Antiretroviral activity of metal-chelating HIV-1 integrase inhibitors. Carcelli M, Rogolino D, Sechi M, Rispoli G, Fisicaro E, Compari C, Grandi N, Corona A, Tramontano E, Pannecouque C, Naesens L. European Journal of Medicinal Chemistry. 2014 Aug 18;83:594-600. doi: 10.1016/j.ejmech.2014.06.055. Epub 2014 Jun 26.
  8. Recent and long-lasting infections: the need for avidity testing in HIV-1 infected subjects. Re MC, Bon I, Grandi N, Miserocchi A, Morini S, Clò A, Furlini G, Gibellini D. New Microbiologica 2012 Oct;35(4):407-14. Epub 2012 Oct 1.

Oral and Poster presentations at Meetings and Conferences:

ORAL COMMUNICATIONS

 

  1. HERV-W group evolutionary history: characterization of the group in non-human primates and identification of highly related sequences in New World Monkeys. Grandi N, Cadeddu M, Blomberg J, Mayer J, Tramontano E. 6th European Congress of Virology (ECV) 19-22 October 2016, Congress Center Hamburg (CCH), Hamburg, Germany.
  2. HERV-W group characterization provides insights for potential innovative therapeutic targets for Multiple Sclerosis and other human diseases. Grandi N, Cadeddu M, Blomberg J, Tramontano E. 3rd Innovative Approaches for novel Antiviral Agents Summer School (IAAASS), September 28th – October 3rd 2016, Pula (CA), Sardinia, Italy.
  3. Phylogenic analysis of human MMTV sequences. Grandi N, Bevilacqua G, Tramontano E. II International Workshop on MMTV and Human Diseases, 22-23 September 2016, Auditorium di Palazzo Blu, Pisa, Italy.
  4. HERV-W presence and evolution within the primates lineage: characterization of the group in non-human primates and identification of highly related elements in New World Monkeys. Grandi N, Cadeddu M, Blomberg J, Mayer J, Tramontano E. XIV Congress of the Italian Federation of Life Sciences (FISV), 20 – 23rd September 2016, Sapienza, University of Rome.
  5. Bioinformatic analysis of HERV-K(HML-6) sequences present in human genome assembly GRCh37/hg19. Cadeddu M, Pisano MP, Grandi N, Blomberg J, Tramontano E. 13th Congress of the Italian Society of Virology (SIV), 14 – 16 September 2015 Orvieto (Italy).
  6. Human Endogenous Retrovirus type w distribution in the human genome: identification and characterization of a new set of proviral sequences in GRCh37/hg19 assembly. Grandi N, Cadeddu M, Blomberg J, Tramontano E. 12th Congress of the Italian Society of Virology (SIV), 22 – 24 September 2014 Orvieto (Italy).
  7. Identification and characterization of HERV-K (HML-10) in GRCh37/hg19 assembly and their possible association with the human diseases. Cadeddu M, Grandi N, Blomberg J, Tramontano E. 2nd Innovative Approaches for Identification of Antiviral Agents Summer School (IAAASS), 28 September – 3 October 2014 Pula, Cagliari (Italy).
  8. The development of chimeric proteins as a new strategy against the HIV-1 infection. Clò A, Morini S, Avanzi S, Musumeci G, Guardiani S, Miserocchi A, Grandi N, Bon I, Muthusamy R, Ripalti A, Gibellini D. Italian Conference on AIDS and Retrovirus (I.C.A.R.), 12 – 14 May 2013 Turin (Italy).
  9. Determination of HIV-1 tropism on cellular DNA: use in clinical practice. Grandi N, Bon I, Clò A, Morini S, Miserocchi A, Gibellini D, Re MC. 40° National Congress of the Italian Society of Microbiology (SIM), October 2012 Riccione (Italy).

POSTERS

  1. HERV-W group evolutionary history: bioinformatics characterization in humans and non human primates genomes. Grandi N, Cadeddu M, Blomberg J, Mayer J, Tramontano E. 5th Sardinian Summer School “From GWAS to function”, 20 – 24 June 2016, Polaris Technology Park, Pula (CA), Italy.
  2. HERV-W complete library as innovative biomarker for Multiple Sclerosis and other human autoimmune diseases. Grandi N, Esposito F, Cadeddu M, Blomberg J, Tramontano E
  3. Human Endogenous Retrovirus type W characterization in genome assembly GRCh37/hg19: an innovative approach for human diseases investigation. Grandi N, Cadeddu M, Blomberg J, Tramontano E. 2nd Innovative Approaches for Identification of Antiviral Agents Summer School (IAAASS), 28 September – 3 October 2014 Pula, Cagliari (Italy).
  4. Identification and genomic characterization of HERV-K(HML-10) in human genome GRCh37/hg19 assembly. Cadeddu M, Grandi N, Vargiu L, Rodriguez-Tomè P, Blomberg J, Tramontano E. XIII Congress of the Italian Federation of Life Sciences (FISV), 24 – 27 September 2014 Pisa (Italy).
  5. Identification and bioinformatics characterization of 98 HERV-K(HML-2) containing proviruses in the human genome assembly GRCh37/hg19. Cadeddu M, Poletti V, Grandi N, Vargiu L, Rodriguez-Tomè P, Calistri A, Blomberg J, Parolin C, Tramontano E. Workshop on Endogenous Retroviruses, 7 – 9 August 2014 Graves Mountain Lodge, Syria (USA).
  6. Prediction of HIV-1 coreceptor usage in paired plasma RNA and proviral DNA from untreated patients by population env-v3 sequencing. Grandi N, Bon I, Turriziani O, Montagna C, Musumeci G, Clò A, Morini S, Miserocchi A, Antonelli G, Gibellini D, Re MC. Italian Conference on AIDS and Retrovirus (I.C.A.R.), 12 – 14 May 2013 Turin (Italy)
  7. An interesting case of elite suppressor. Morini S, Grandi N, Bon I, Clò A, Miserocchi A, Musumeci G, Gibellini D, Re MC. Italian Conference on AIDS and Retrovirus (I.C.A.R.), 12 – 14 May 2013 Turin (Italy)
  8. The importance of avidity testing in HIV infected patients surveillance. Musumeci G, Grandi N, Clò A, Morini S, Miserocchi A, Bon I, D’Arcangelo M, Nemi ML, Coppola C, Gibellini D, Re MC. Italian Conference on AIDS and Retrovirus (I.C.A.R.), 12 – 14 May 2013 Turin (Italy)
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